TABLE 1.
Neutralization sensitivity of HIV-1 clade C isolates as measured with sCD4 and human monoclonal antibodies
| Reagent | ID80 (μg/ml) for isolatea
|
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| South African
|
Malawian
|
||||||||||||||||
| Du123 | Du151 | Du156 | Du172 | Du174 | Du179 | Du368 | Du422 | S080 | S021 | S009 | S018 | S007 | S180 | S017 | S103 | ||
| rsCD4 | >50 | >50 | >50 | >50 | >50 | 41 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | |
| 2G12 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | |
| IgG1b12 | 16 | 50 | >50 | 29 | >50 | >50 | 30 | 23 | 33 | >50 | 50 | 2 | >50 | >50 | >50 | <2 | |
| 2F5 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | 49 | >50 | >50 | >50 | >50 | >50 | 7 | |
a
Values below each virus strain are the minimum concentration of sCD4 and monoclonal antibodies 2G12, IgG1b12, and 2F5 required to achieve an 80% reduction in p24 synthesis in PBMC (ID80). Positive neutralization is shown in boldface type.