TABLE 5.
Cross-neutralizing activity of serum samples from three subjects infected with clade C HIV-1
| Subject | No. (%) of HIV-1 isolates neutralized by 1:20-diluted seruma
|
||
|---|---|---|---|
| Clade B (n = 35) | Clade C (n = 15) | Totalb (n = 50) | |
| Du151 | 12 (34) | 8 (53) | 20 (40) |
| Du156 | 6 (17) | 2 (13) | 8 (16) |
| Du368 | 3 (9) | 1 (7) | 4 (8) |
a
Serum samples from subjects Du151 (17.3 months), Du156 (17 months), and Du368 (27 months) were assayed at a 1:20 dilution with 35 clade B and 15 heterologous clade C primary HIV-1 isolates. Neutralization was considered positive if p24 synthesis was reduced ≥80% relative to a negative control (serum from a healthy, HIV-1-negative individual). Values do not include autologous virus-serum combinations.
b
This is the fraction and percent of isolates neutralized for the 50 isolates total.