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. 2026 Jun 20;4(9):2150–2157. doi: 10.1021/envhealth.6c00088

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© 2026 The Authors. Co-published by Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, and American Chemical Society

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(a–e) Time-dependent kinetics of PFAS transport by wild-type HEK293 cells (black rectangles), human OAT1-transfected HEK293 cells (teal circles), and net human OAT1-mediated PFAS transport (red triangles). Net uptake was obtained by subtracting the uptake values for wild-type cells from OAT1-transfected cells. (f) Concentration-dependent net uptakes of PFAS at 1 min. The net concentration-dependent OAT1-mediated uptake was fitted to the Michaelis–Menten equation. Each point represents mean ± SD of triplicates.