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. 2026 Sep 21;28:e92090. doi: 10.2196/92090

Table 2. Comparing the fact-checking performance of multiple open-source large language models (LLMs) and the proprietary GPT-4o (the baseline used in previous experiments)a.

Evaluation metricb GPT-4o (baseline) Gemma 3 27B MedGemma 27B Llama 3 70B OpenBioLLM 70B Qwen 3 32B Qwen 3 Medical 32B
TPc 6 6 11 12 7 8 8
FPd 3 3 3 2 1 2 3
TNe 89 84 84 78 79 83 82
FNf 2 7 2 8 14 6 7
Sensitivity (recall) 78 46 83 61 33 56 55
Specificity 96 97 97 97 99 98 96
Precision (PPVg) 66 68 79 83 88 80 72
F1-score 71 55 81 70 48 66 63
Accuracy 95 90 95 90 86 92 90
Balanced accuracy 87.3 71 90 79 66 77 76
TP improved atoms 100 100 91 98 100 82 89
FP falsified atoms 0 30 44 50 0 0 14
Overall answer quality improved 20 20 30 8 4 18 24
Overall answer quality equal 14 8 6 4 4 8 22
Overall answer quality worse 8 4 6 6 10 16 10
Hallucination rate 1 2 3 6 11 4 2
Hallucination detection 50 71 80 52 50 69 60
Inaccuracy rate 3 2 3 5 3 3 4
Inaccuracy detection 58 38 90 68 22 21 44
a

The focus was on general-purpose vs medical fine-tuned models of different sizes: Gemma 3 27B vs MedGemma 27B; Llama 3 70B vs OpenBioLLM 70B; and Qwen 3 32B vs Qwen 3 Medical 32B.

b

Numbers represent the percentage values.

c

TP: true positive.

d

FP: false positive.

e

TN: true negative.

f

FN: false negative.

g

PPV: positive predictive value.