FIG. 1.

Structures of scrapin genes and proteins. (A) Sequence of MV-LAP. The open reading frame corresponding to the protein is shown with amino acids in single-letter code below the DNA sequence. Star, stop codon; downward-pointing arrow, frameshift with the sequence published by Cameron et al. (9); underlined letters, early termination signal; boxed letters, C₄HC₃ (LAP) motif; shadowed letters, transmembrane domains. (B) C₄HC₃ (LAP) motif of viral scrapins. SFV, Shope fibroma virus; SPV, swinepox virus; BHV4, bovine herpesvirus 4; MHV68, mouse herpesvirus 68; HSV, herpesvirus saimiri. (C) General structure of viral scrapins. C₄HC₃, LAP motif; TM, transmembrane domain. Numbers above the diagrams, positions of amino acids flanking the LAP motifs; numbers on the right, lengths of the proteins.