TABLE 1.

Pathogenicity of MV-LAP in European rabbits

Day	Procedure or result
	Wild type MV and MV-LAP-reva	MV-ΔLAP mutantb
0	Intradermal inoculation of four rabbits with 5,000 PFU of the wild-type MV strain T1 and of four rabbits with 5,000 PFU of MV-LAP-rev	Intradermal inoculation of 12 rabbits with 5,000 PFU
4	Primary lesions at inoculation sites: soft, congested, ca. 1 cm	Primary lesions at inoculation sites: soft, congested, ca. 1.5 cm
7	Primary myxomas large and diffused. Gram-negative bacterial infections of nasal and conjunctival mucosa. Multiple secondary myxomas on face and ears; edema of the testicles.	Primary myxomas large and diffused. Gram-negative bacterial infections on nasal and conjunctival mucosa. Secondary myxomas on face and ears; edema of the testicles.
12	Multiple secondary myxomas turning necrotic. Dyspnea; severe infection of respiratory tract. Emaciated; prostrated. Severe inflammation of the testicles. All rabbits sacrificed because of increased severity of symptoms.	Few secondary myxomas, mostly on eyelids. Moderate to severe infection of respiratory tract. Mild inflammation of the testicles.
14		4/12 rabbits sacrificed
21		Decrease in respiratory signs; 8/12 rabbits recover and are sacrificed at day 28

^aRabbit survival: 0 of 4 and 0 of 4.

^bRabbit survival: 8 of 12.