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. Author manuscript; available in PMC: 2026 Sep 23.
Published in final edited form as: Mol Cell. 2026 Aug 6;86(16):3185–3197.e7. doi: 10.1016/j.molcel.2026.07.012

Figure 1: Overview of BRD4/H4 K12acK16ac nucleosome structure.

Figure 1:

(a) Cryo-EM map and (b) cartoon representation of the BRD4-S/H4 K12acK16ac nucleosome complex showing how the BRD4 BD1 (pink) interacts with the nucleosome. The modeled histone H4 tail residues 11–16 are shown as a thicker gold line. The locations of the BRD4-S structured domains are shown below together with the color key for the figures.