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. Author manuscript; available in PMC: 2026 Sep 23.
Published in final edited form as: Mol Cell. 2026 Aug 6;86(16):3185–3197.e7. doi: 10.1016/j.molcel.2026.07.012

Figure 3: BRD4 basic patches mediate redundant interactions with H4 K12acK16ac nucleosomes.

Figure 3:

(a) BRD4-S domains and basic patches highlighted in cartoon and primary sequence (left) and identity of BRD4-S basic patch mutations studied (right), (b) TR-FRET dissociation constants for BRD4-S basic patch mutants binding to H4 K12acK16ac nucleosomes in 70 mM NaCl, (c) TR-FRET dissociation constants for BRD4-S basic patch mutants binding to H4 K12acK16ac nucleosomes in 150 mM NaCl, (d) effect of salt concentration on select BRD4-S basic patch mutations on binding to H4 K12acK16ac nucleosomes.