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. Author manuscript; available in PMC: 2026 Sep 23.
Published in final edited form as: Mol Cell. 2026 Aug 6;86(16):3185–3197.e7. doi: 10.1016/j.molcel.2026.07.012

Figure 7: Modified histone peptide is exposed in BRD4/nucleosome complex compared to other chromatin reader/nucleosome complexes.

Figure 7:

BRD4-S bromodomain 1/H4 K12acK16ac nucleosome (this work), LEDGF PWWP domain/H3 K36me3 nucleosome (PDB 6S01), ORCA/Orc2/H4 K20me3 nucleosome (PDB 8SIY), 53bp1Tudor domain/gH2AX K15ub-H4 K20me2 nucleosome (PDB 7YQK). The chromatin reader protein is show in pink and the modified lysine residue is shown in dark blue. Histones H2A, H2B, H3 and H4 are shown in yellow, red, blue and green and nucleosomal DNA is show in grey.