TABLE 1.
Expression of chemokines by HSV-infected PCsa
| Chemokine | Changes in expression levelb
|
|
|---|---|---|
| HSV-1 | HSV-2 | |
| 6Ckine/CCL21 | NDc | ND |
| C10/CCL6 | 0.90 | 1.38 |
| Eotaxin/CCL11 | ND | ND |
| MIP-1α/CCL3 | 1.19 | 2.18 |
| MIP-1β/CCL4 | 0.81 | 0.80 |
| MIP-1γ/CCL9 | 1.03 | 1.29 |
| MIP-2α/CXCL2 | 1.08 | 1.06 |
| MIP-3α/CCL20 | ND | ND |
| MIP-3β/CCL19 | 1.15 | 0.76 |
| JE/MCP-1/CCL2 | 0.98 | 0.90 |
| MARC/MCP-3/CCL7 | ND | ND |
| MCP-5/CCL12 | 1.01 | 1.12 |
| TCA3/CCL1 | 0.88 | 1.19 |
| MDC/CCL22 | ND | ND |
| RANTES/CCL5 | 8.07 | 9.84 |
| c-Tack/CCL27 | ND | ND |
| TECK/CCL17 | ND | ND |
| TECK/CCL25 | 0.91 | 0.54 |
| CCL28 | ND | ND |
| BLA/BCA-1/CXCL13 | 7.66 | 7.48 |
| BRAK/CXCL14 | ND | ND |
| IP-10/CXCL10 | 1.17 | 0.72 |
| GCP-2/CXCL6 | ND | ND |
| GROα/CXCL1 | 0.70 | 0.63 |
| Lungkine/CXCL15 | ND | ND |
| MIG/CXCL9 | 0.89 | 1.15 |
| SDF-1/CXCL12 | ND | ND |
| Lymphotaxin/CX3CL1 | 1.03 | 0.76 |
a
PCs were treated with a mock preparation or infected with HSV-1 and -2 at an MOI of 1. Twenty-four hours later, total RNA was isolated, cleared of potential DNA contaminations, and analyzed for the presence of chemokine mRNAs by using cDNA arrays.
b
Normalized mRNA levels in infected cells were compared to the levels in mock-treated cells. Values are ratios of levels in infected cells to those in mock-infected cells.
c
ND, not detectable after 30 days of exposure.