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. 2002 Mar;76(6):2721–2729. doi: 10.1128/JVI.76.6.2721-2729.2002

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Copyright © 2002, American Society for Microbiology.

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FIG. 1. — Schematic representations of the HBV genome and enhancer 1 element. (A) The viral genome is numbered (0 to 3,200 bp) according to the adw2 subtype of HBV. S, C, P, and X represent the viral genes encoding the surface antigen, core or e antigen, DNA polymerase, and X proteins, respectively. The HBV promoters (preS1, preS2, Cp, and Xp) and enhancers (Enh 1 and Enh 2) are indicated. A_n represents the single polyadenylation site used by all of the HBV RNAs. Each viral transcript is labeled with its respective length in kilobases (kb) and a poly(A) tail at the 3′ end. Multiple transcription initiation sites are indicated at the 5′ end of the 3.5-, 2.1-, and 0.9-kb RNAs. (B) Protein binding sites on Enh 1 are shown and footprint designations previously defined (38) are indicated above the corresponding sites. (C) The core domain spans nt 1080 to 1165 and is composed of the STAT-3 binding site, which is located at nt 1111 to 1127. The HNF-3 binding site spans nt 1124 to 1139. The DNA sequence of the STAT-3/HNF-3 region is shown with the corresponding cellular factors as indicated above. The thin line and arrows below the STAT-3-HNF-3 region indicate the positions of STAT-3 and FPV direct repeats, respectively.

FIG. 1. — Schematic representations of the HBV genome and enhancer 1 element. (A) The viral genome is numbered (0 to 3,200 bp) according to the adw2 subtype of HBV. S, C, P, and X represent the viral genes encoding the surface antigen, core or e antigen, DNA polymerase, and X proteins, respectively. The HBV promoters (preS1, preS2, Cp, and Xp) and enhancers (Enh 1 and Enh 2) are indicated. A_n represents the single polyadenylation site used by all of the HBV RNAs. Each viral transcript is labeled with its respective length in kilobases (kb) and a poly(A) tail at the 3′ end. Multiple transcription initiation sites are indicated at the 5′ end of the 3.5-, 2.1-, and 0.9-kb RNAs. (B) Protein binding sites on Enh 1 are shown and footprint designations previously defined (38) are indicated above the corresponding sites. (C) The core domain spans nt 1080 to 1165 and is composed of the STAT-3 binding site, which is located at nt 1111 to 1127. The HNF-3 binding site spans nt 1124 to 1139. The DNA sequence of the STAT-3/HNF-3 region is shown with the corresponding cellular factors as indicated above. The thin line and arrows below the STAT-3-HNF-3 region indicate the positions of STAT-3 and FPV direct repeats, respectively.

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