Amino acid sequence alignment of the Tva LDL-A module, LDL-A22 of LRP2, and all LDL-A modules with known structures: LDL-A5, LDL-A1, LDL-A2, LDL-A6, LRP CR3, and CR8. Conserved amino acids are boxed, and the six residues involved in calcium coordination are shaded. The residues of the Tva LDL-A module from both quail and chickens are numbered from 11 to 50 according to the mature Tva (2).