TABLE 2.
Adjuvant effect of the adenoviral recombinantsa
Source of cytokine | Amt of IFN (U) |
|
---|---|---|
Without XMG1 | With XMG1 | |
Splenocytes + Adhu5rab.gp | 2 | 2 |
Splenocytes + AdC68rab.gp | 12 | 12 |
Splenocytes without virus | ≤0.5 | |
Recombinant mouse IFN-γ | 1024 | 8 |
Splenocytes from naïve C3H/He mice were cultured with 10 PFU of the adenoviral recombinants per cell. Cell-free supernatants were tested for IFN without and with addition of the XMG1 antibody to IFN-γ. A recombinant IFN-γ was tested in parallel.