FIG. 1.

Sequences comparison of the P proteins from residues 161 to 180 among several pneumoviruses and the mutants analyzed. RSV-A2, human RSV subgroup A2; RSV-B1, human RSV subgroup B1; ORSV, ovine RSV; BRSV, bovine RSV; APV, avian pneumovirus; PVM, pneumonia virus of mice. Mutants analyzed in this study: G172S, Gly replaced by Ser at position 172; E176G, Glu replaced by Gly at position 176; G172S/E176G, double mutant containing both G172S and E176G; 174-176A, three consecutive charged residues from positions 174 to 176 replaced by Ala; Δ161-180, an internal deletion from residues 161 to 180; ΔC6, a C-terminal deletion from residues 236 to 241.