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Alignment of the amino acid sequences of the NS5A proteins encoded by NNeo/3-5B and BNeo/3-5B. The ISDR is shaded, with the 4-amino-acid -Ser-Ser-Tyr-Asn- insertion in NNeo/3-5B shown in boldface type and enclosed in a box. Arrows indicate the location of single-base substitutions and insertions and the large 47-amino-acid deletion that has been shown previously to enhance the replication capacity of BNeo/3-5B (4, 14, 15). The asterisk indicates the S2005I mutation.
