FIG. 1.

Model for studying the interplay between virus and B-cell lymphoma. A syngeneic BMT is carried out with female BALB/c mice as BM cell donors and recipients. Hematoablative conditioning of the recipients is achieved by gamma irradiation with a single dose of 6 or 7 Gy. Recipients receive B-lymphoma cells of A20 (ATCC TIB-208)-derived liver-adapted clone E12E. One group of recipients is infected with mCMV, and another group is left uninfected for control. Tumor pathogenicity is tested by monitoring survival and symptoms of illness, and tumorigenicity is determined by histomorphometrical quantitation of lymphoma growth in the liver.