ADC	Antibody–drug conjugate
ADCC	Antibody-dependent cellular cytotoxicity
ADCP	Antibody-dependent cellular phagocytosis
AKT	Protein kinase B
APC	Adenomatous polyposis coli
B7-H3	B7 homolog 3
BiTE	Bispecific T cell engager
BRAF	B-Raf proto-oncogene, serine/threonine kinase
bsAb	Bispecific antibody
bsADC	Bispecific antibody–drug conjugate
CAB	Conditionally active biologic
CAR	Chimeric antigen receptor
CD3	Cluster of differentiation 3
CD8	Cluster of differentiation 8
CD44	Cluster of differentiation 44
CD47	Cluster of differentiation 47
CD133	Cluster of differentiation 133/prominin-1
CD137/4-1BB	Cluster of differentiation 137
CD166	Cluster of differentiation 166/activated leukocyte cell adhesion molecule (ALCAM)
CDC	Complement-dependent cytotoxicity
CDH17	Cadherin-17
CEACAM5	Carcinoembryonic antigen-related cell adhesion molecule 5
CH3	Constant heavy chain domain 3
CLDN18.2	Claudin 18.2
c-MET	Mesenchymal–epithelial transition factor (MET receptor)
CPT2	Camptothecin 2
CRC	Colorectal cancer
CSC	Cancer stem cell
CTLA-4	Cytotoxic T-lymphocyte-associated protein 4
DAR	Drug-to-antibody ratio
dMMR	Deficient mismatch repair
DNA	Deoxyribonucleic acid
DXd	Deruxtecan
EGFR	Epidermal growth factor receptor
EpCAM	Epithelial cell adhesion molecule
EphA-2	Ephrin type-A receptor 2
Fc	Fragment crystallizable region
FcγR	Fc gamma receptor
FOLFIRI	Folinic acid, fluorouracil, and irinotecan
FOLFOX	Folinic acid, fluorouracil, and oxaliplatin
GI	Gastrointestinal
GPCR	G protein-coupled receptor
GUCY2C	Guanylate cyclase 2C
HC	Heavy chain
HER2	Human epidermal growth factor receptor 2
HER3	Human epidermal growth factor receptor 3
HLA	Human leukocyte antigen
IgG	Immunoglobin G
IgG1	Immunoglobin G1
ISC	Intestinal stem cell
KRAS	Kirsten rat sarcoma viral oncogene homolog
LAG-3	Lymphocyte activation gene 3
LC	Light chain
LGR5	Leucine-rich repeat-containing G protein-coupled receptor 5
LY6G6D	Lymphocyte Antigen 6 Family Member G6D
mAb	Monoclonal antibody
MAPK	Mitogen-activated protein kinase
mCRC	Metastatic colorectal cancer
MHC	Major histocompatibility complex
MLH1	MutL homolog 1, mismatch repair system component
MMAE	Monomethyl auristatin E
MMAF	Monomethyl auristatin F
MSH2	MutS homolog 2, mismatch repair system component
MSH6	MutS homolog 6, mismatch repair system component
MSI	Microsatellite instability
MSI-high	Microsatellite instability-high
MSS	Microsatellite stable
MTD	Maximum tolerated dose
NK	Natural killer
NSCLC	Non-small cell lung cancer
PBD	Pyrrolobenzodiazepine
PD-1	Programmed cell death protein 1
PD-L1	Programmed death-ligand 1
PI3K	Phosphoinositide 3-kinase
PI3KCA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha
PMS2	PMS1 homolog 2, mismatch repair system component
RAS	Rat sarcoma (RAS family of small GTPases)
RSL3	RAS-selective lethal 3
RTK	Receptor tyrosine kinase
scFv	Single-chain variable fragment
SCLC	Small cell lung cancer
SMAD4	SMAD family member 4
TCR	T cell receptor
T-DXd	Trastuzumab deruxtecan
TNFR2	Tumor necrosis factor receptor 2
Top1i	Topoisomerase I inhibitor
TP53	Tumor protein p53
TRAE	Treatment-related adverse event
VEGF	Vascular endothelial growth factor
VEGFR2	Vascular endothelial growth factor receptor 2