Table 3.

Clinicopathological and molecular features of BRAF mutant colorectal cancers stratified according to microsatellite instability status.

	MSI-			MSI+
Feature	BRAF WT (n = 192) (%)	BRAF M (n = 9) (%)	P	BRAF WT (n = 19) (%)	BRAF M (n = 12) (%)	P
Age (years)	68.5 ± 12.6	58.2 ± 26.5	NS	67.5 ± 16.8	76.1 ± 10.9	NS
Females	39	44	NS	63	75	NS
TILS + a	3	44	0.0004	28	60	0.08
Node negative	62	62	NS	81	89	NS
Proximal site	36	67	0.05	72	89	NS
Poor grade	15	40	0.12	25	56	0.11
Mucinous	12	53	0.05	6	44	0.04
CIMP+	15	50	0.03	40	88	0.03
Dist. MLH1 methylated	7	12	NS	40	75	0.10
Prox. MLH1 methylated	1	0	NS	33	75	0.06
KRAS mutant	43	0	0.008	21	0	0.12
TP53 mutant	29	11	NS	5	18	NS

^aTumor-infiltrating lymphocytes