Table 3.
Driving signatures and ontologies of gene clusters on different matrixes
| Cluster | Driving signature | Ontology |
| Matrigel_1 | J82 underexpressed | negative regulation of biological process |
| Matrigel_2 | JP underexpressed | mRNA processing |
| Matrigel_3 | HUC & JB overexpressed | mismatch repair; transcription factor activity |
| Matrigel_4 | HUC underexpressed | anti-apoptosis; induction of apoptosis by extracellular signals; protein binding; protein serine/threonine kinase activity |
| Matrigel_5 | JB underexpressed | regulation of cyclin dependent protein kinase activity; mitotic control; negative regulation of cell proliferation |
| Matrigel_6 | JB & J82 underexpressed | |
| Matrigel_7 | J82 & JP overexpressed | regulation of cyclin dependent protein kinase activity; anti-apoptosis; negative regulation of cell proliferation; positive regulation of cell proliferation; extracellular space |
| Plastic_1 | JP underexpressed | induction of apoptosis |
| Plastic_2 | JP underexpressed RT4 overexpressed |
immune response |
| Plastic_3 | TCCSUP & J82 overexpressed | negative regulation of cell cycle |
| Plastic_4 | TCCSUP underexpressed | protein kinase cascade; meiotic recombination; cell cycle arrest; anti-apoptosis; induction of apoptosis by extracellular signals; protein ubiquitination; nucleotide-excision repair; protein binding; nucleus |
| Plastic_5 | mitotic cell cycle; chromosome | |
| Plastic_6 | J82 underexpressed | cell cycle arrest; nucleus |
| Plastic_7 | HUC underexpressed | negative regulation of cellular process; antioxidant activity; extracellular matrix |
| SISgel_1 | J82 & JP overexpressed | cell cycle; induction of apoptosis; extracellular matrix |
| SISgel_2 | HUC underexpressed J82 overexpressed |
regulation of cell cycle; negative regulation of cell proliferation; inflammatory response |
| SISgel_3 | JB underexpressed | induction of apoptosis by extracellular signals; DNA replication; purine nucleotide biosynthesis; ligase activity, forming carbon-nitrogen bonds; cytoskeleton |
| SISgel_4 | JB overexpressed | |
| SISgel_5 | RT4 underexpressed | negative regulation of cell cycle |
| SISgel_6 | J82 underexpressed | cell division; protein complex assembly |