Table 2.
Associations with depression in patients with newly diagnosed T2DM.
| Depression |
|||||
|---|---|---|---|---|---|
| COR (CI 95%) | P | AOR (CI 95%) | Pa | ||
| Age (per year) | 0.99 (0.97–1.00) | <0.11 | – | – | |
| Sex (women) | 1.8 (1.2–2.7) | 0.003 | 1.3 (0.8–2.2) | 0.26 | |
| Anxiety | 10.2 (6.6–15.7) | <0.001 | 10.5 (6.3–17.4) | <0.001 | |
| Antidepressants | 3.3 (1.9–5.7) | <0.001 | – | – | |
| sTREM2 quintiles (pg/mL) | >3.38 | 2.0 (1.1–3.7) | 0.023 | – | – |
| >2.28 – ≤3.38 | 1.4 (0.7–2.6) | 0.31 | – | – | |
| >1,71 – ≤2.28 | 0.9 (0.5–1.8) | 0.83 | – | – | |
| >1.27 – ≤1,71 | 0.9 (0.46–1.8) | 0.76 | – | – | |
| ≤1,27 | 1 | – | – | ||
| High sTREM2 (≥1.60 nmol/L) | 1.9 (1.2–3.0) | 0.004 | 2.0 (1.1–3.5) | <0.016 | |
| Low sNeuropilin-1 (<225.5 ng/mL) | 3.2 (2.1–4.9) | <0.001 | 3.3 (2.0–5.5) | <0.001 | |
| High C-peptide (≥1.60 nmol/L) | 1.7 (1.1–2.7) | 0.009 | 1.9 (1.1–3.2) | 0.024 | |
| HbA1c | (per %) | 1.0 (0.9–1.1) | 0.43 | – | – |
| (per mmol/mol) | 1.00 (0.99–1.01) | – | – | ||
| BMI (per kg/m2) | 1.05 (1.01–1.08) | <0.006 | 1.02 (0.97–1.06) | 0.44 | |
| Physical inactivity | 1.8 (1.1–2.7) | 0.010 | 1.8 (1.1–3.0) | 0.025 | |
| Smoking | 1.7 (1.0–2.9) | 0.043 | 1.3 (0.7–2.5) | 0.41 | |
| Stroke/TIA (prior) | 0.8 (0.4–1.8) | 0.61 | – | – | |
| Myocardial infarction (prior) | 1.1 (0.6–2.1) | 0.69 | – | – | |
a
Logistic regression (Backward: Wald): n = 630; Omnibus Tests of Model Coefficients p < 0.001; Nagelkerke R2 0.336.