Figure 2.

Cumulative probability of terminal renal failure. The cumulative probability of terminal renal failure was determined for 24 patients from the large kindred with adolescent nephronophthisis (solid lines) and was compared with that in a historical sample of genetically proved NPH1 (dashed lines [Hildebrandt et al. 1997b]), by use of the life-table method of Kaplan and Meier (1958). The data were compared by use of the Wilcoxon test. In the group with adolescent nephronophthisis, one patient, and, in the group with NPH1, four patients, were censored (vertical strokes), because terminal renal failure did not occur during the observation period.