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. 2006 Jan;13(1):27–34. doi: 10.1101/lm.91206

Figure 2.

Figure 2.

Extended re-exposure inhibitory avoidance behavior. Rats in Experiment 2 were left in the shock compartment for 200 sec after entering it on the test days. Data are given as groups' mean latencies to cross into the shock context at each trial. (A) All groups learned to avoid the dark shock compartment [(*) P < 0.05, (**) P < 0.001 vs. training]. Vehicle controls showed extinction from Test 1 to Test 2 [(#) P < 0.05 vs. Test 1 within group] and from Test 2 to Test 3 [(‡) P < 0.05 vs. Test 2 within group]. Rats given anisomycin after Test 1 did not show extinction between Tests 1 and 2 [P > 0.05 vs. Test 1 within group; (†) P < 0.05 vs. vehicle within trial], but did show subsequent extinction in the absence of the drug from Test 2 to Test 3 [(‡‡) P < 0.001 vs. Test 2 within group]. Anisomycin treatment without a Test 1 context re-exposure did not affect retention; however, these rats showed subsequent extinction in the absence of drug from Test 2 to Test 3 [(‡‡) P < 0.001 vs. Test 2 within group]. The mild reminder shock given in Test 3 reinstated robust avoidance of the shock compartment in all groups, with the anisomycin-treated groups showing greater avoidance after the reminder shock than the vehicle group [(†) P < 0.05 vs. vehicle within trial]. (B) The savings revealed by the mild reminder shock on day 6 in the individual rats of each group is shown.