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. 2006 Jan;13(1):52–62. doi: 10.1101/lm.126306

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Figure 2. — Systemic administration of WAY-100635 (WAY) blocks LTP induction in awake freely moving animals exploring novel environments. (A) Point plot of averaged medial perforant path-dentate field EPSP slopes (±SEM) showing baseline responses, responses 25-30 min after application of drug, and 1 h following tetanus. Systemic WAY attenuated LTP in doses of 0.5 (▴) and 0.01 mg/kg (○), (P < 0.05). The 0.005 mg/kg dose () did not differ significantly from controls receiving only the water vehicle (▵), (n = 4/group). Traces are representative responses collected 20-25 min following administration of either (a) the water vehicle or (b) 0.5 mg/kg of WAY, and responses collected 1 h after delivery of θ trains. Calibration: 1 mV, 5 msec. (B) Comparison of the time course of LTP over a 2-wk period induced following administration of the water vehicle (▿) or 0.005 (•), 0.01 (○) or 0.5 mg/kg of WAY (▾), (n = 4/group). WAY in doses of 0.01 and 0.5 mg/kg attenuated significantly the duration of LTP as compared with LTP induced in the presence of the vehicle (P < 0.05).

Inline graphic — Systemic administration of WAY-100635 (WAY) blocks LTP induction in awake freely moving animals exploring novel environments. (A) Point plot of averaged medial perforant path-dentate field EPSP slopes (±SEM) showing baseline responses, responses 25-30 min after application of drug, and 1 h following tetanus. Systemic WAY attenuated LTP in doses of 0.5 (▴) and 0.01 mg/kg (○), (P < 0.05). The 0.005 mg/kg dose () did not differ significantly from controls receiving only the water vehicle (▵), (n = 4/group). Traces are representative responses collected 20-25 min following administration of either (a) the water vehicle or (b) 0.5 mg/kg of WAY, and responses collected 1 h after delivery of θ trains. Calibration: 1 mV, 5 msec. (B) Comparison of the time course of LTP over a 2-wk period induced following administration of the water vehicle (▿) or 0.005 (•), 0.01 (○) or 0.5 mg/kg of WAY (▾), (n = 4/group). WAY in doses of 0.01 and 0.5 mg/kg attenuated significantly the duration of LTP as compared with LTP induced in the presence of the vehicle (P < 0.05).