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. 2006 Jan;13(1):52–62. doi: 10.1101/lm.126306

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Copyright © 2006, Cold Spring Harbor Laboratory Press

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Figure 4. — Direct application of WAY to the dentate gyrus blocks LTP induction in pentobarbital-anesthetized animals. Plot of medial perforant path-dentate field EPSP slopes (±SEM) following the application of WAY or the lactated Ringer's vehicle to the dentate and 1 h following theta trains. The 7 nmol (▴) and 3 nmol (○) nmol quantities of WAY significantly attenuated LTP magnitude, whereas the 1 nmol () did not alter LTP magnitude as compared with LTP observed following application of the lactated Ringer's vehicle (▵), (n = 3/group, P < 0.05). In addition, the initial short-term potentiation (STP), reflected in magnitude of potentiation immediately after delivery of theta trains, also was attenuated dose dependently by WAY (P < 0.05). Traces are representative of responses collected 5-10 min after application of the vehicle (a) or a 7-nmol quantity of WAY (b), and 1 h after delivery of θ trains. Calibration: 1 mV, 5 msec.

Inline graphic — Direct application of WAY to the dentate gyrus blocks LTP induction in pentobarbital-anesthetized animals. Plot of medial perforant path-dentate field EPSP slopes (±SEM) following the application of WAY or the lactated Ringer's vehicle to the dentate and 1 h following theta trains. The 7 nmol (▴) and 3 nmol (○) nmol quantities of WAY significantly attenuated LTP magnitude, whereas the 1 nmol () did not alter LTP magnitude as compared with LTP observed following application of the lactated Ringer's vehicle (▵), (n = 3/group, P < 0.05). In addition, the initial short-term potentiation (STP), reflected in magnitude of potentiation immediately after delivery of theta trains, also was attenuated dose dependently by WAY (P < 0.05). Traces are representative of responses collected 5-10 min after application of the vehicle (a) or a 7-nmol quantity of WAY (b), and 1 h after delivery of θ trains. Calibration: 1 mV, 5 msec.