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. 2025 Dec 15;48(5):7175–7190. doi: 10.1007/s11357-025-02028-3

Table 2.

Published percent lifespan increases for mice for interventions used in this study

Intervention Dose Lifespan percent increase (males, females) Citation
Rapamycin (Rapa) 14.7 ppm 23, 26 [30]
Acarbose (Aca) 1000 ppm 22, 5 [3]
17α-estradiol (17aE2) 14 ppm 12, 0 [3]
Canagliflozin (Cana) 180 ppm 14, 0 [6]
Caloric restriction (CR) 60% 32, 40 Table 1 of [31]
Growth Hormone Receptor Knockout (GHRKO) Mutant 18, 24 Table 2 of [14]
Snell Dwarf Mutant 49, 68 Table 2 of [32]