Table 3.
Metabolite name and SHAP value rank
| Rank | Feature name | Rank | Feature name |
|---|---|---|---|
| 1 | N-methylisoleucine | 11 | N-acetyltyrosine |
| 2* | TG 57:9|TG 17:1_18:2_22:6 | 12* | TG 64:16|TG 20:4_22:6_22:6 |
| 3* | TG 48:3|TG 14:0_16:1_18:2 | 13* | TG O-53:9|TG O-19:5_17:2_17:2 |
| 4* | TG 56:9|TG 16:1_18:2_22:6 | 14 | N-acetylaspartylglutamic acid |
| 5 | N-omega-acetylhistamine | 15 | SM 42:1;2O |
| 6 | Ergothioneine | 16 | Sulfamethoxazole |
| 7 | 1-(piperidin-4-yl)ethan-1-ol | 17* | TG 58:8|TG 18:1_18:2_22:5 |
| 8 | 3-hydroxysebacic acid | 18 | N8-acetylspermidine |
| 9* | TG 62:14|TG 18:2_22:6_22:6 | 19 | SM 36:1;2O|SM 18:1;2O/18:0 |
| 10* | TG 50:3|TG 16:0_16:1_18:2 | 20 | 1-hexadecanoyl-2-octadecadienoyl-sn-glycero-3-phosphocholine |
The metabolites from the FM dataset listed in order of SHAP importance, i.e., influence of the metabolite on predicted percentage lifespan increase. The * indicates that the metabolite is a lipid. TG is an abbreviation for triacylglyceride. Supplemental Table 3 has the mean absolute SHAP values for these 20 features