Figure 4.

Influence of DLC-1 expression on the migration and invasion of M4A4 cells. A, the rate of cell migration was assessed by induction of movement toward serum through an uncoated membrane in a modified Boyden chamber assay. B, cell invasiveness was assessed by the movement toward serum through Matrigel-coated membranes. Columns, means of triplicate determinations for each experiment; bars, SE. A one-way ANOVA was used to calculate the overall P value for comparisons between all four groups. The Newman-Keuls posttest was used for individual comparisons, as indicated. M4A4-DLC1, M4A4 cells stably transduced with DLC1. M4A4-neo, M4A4 cells were transduced with appropriate vector only.