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. Author manuscript; available in PMC: 2006 Feb 2.
Published in final edited form as: Dev Biol. 2005 Jul 15;283(2):345–356. doi: 10.1016/j.ydbio.2005.04.028

Fig. 1.

Fig. 1

Diagrams of Runx2 alleles and gene products in non-selective Runx2 and selective Runx2-II-deficient mice. (A) Heterozygous Runx2+/− mice have one copy of wild-type Runx2 alleles predicted to generate 1/2 of the normal Runx2-I and Runx2-II gene products. (B) Homozygous Runx2−/− mice have neither wild-type Runx2 alleles nor Runx2-I and Runx2-II gene products. (C) Heterozygous Runx2-II+/− mice have one wild-type Runx2 allele and one Runx2-II mutant allele. These mice should express normal amounts of Runx2-I and 1/2 the amount of Runx2-II gene products. (D) Homozygous Runx2-II−/− mice have two mutant Runx2-II alleles predicted to produce normal amounts of Runx2-I but no Runx2-II gene products. P1 or P2 designates the promoter regions for Runx2-II or Runx2-I, respectively.