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. Author manuscript; available in PMC: 2006 Feb 2.
Published in final edited form as: Dev Biol. 2005 Jul 15;283(2):345–356. doi: 10.1016/j.ydbio.2005.04.028

Fig. 3.

Fig. 3

3D images of femurs in 6- and 24-week wild-type and mutant mice. 3D images of metaphyseal bone (upper panel) and cortical bone (lower panel) generated from μCT analysis. There was an age-dependent reduction in trabecular bone volume and an increase in cortical thickness in wild-type mice. The trabecular bone volume and cortical thickness was reduced in Runx2-II+/− and Runx2-II−/− mice proportionate to the reduction in gene dosage. Runx2-II+/− mice displayed an age-dependent decrease in trabecular bone and increase in cortical bone similar to wild-type mice.