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. Author manuscript; available in PMC: 2007 Jan 15.
Published in final edited form as: Cancer Res. 2006 Jan 15;66(2):960–969. doi: 10.1158/0008-5472.CAN-05-2388

Figure 5.

Figure 5

Induction of immune response upon oncolysis with Ad.IR-E1A/TRAIL.A) Mice were subcutaneously injected with 2×104 TC-1 cells. When tumors reached a diameter of 2mm, one group of mice (right panel) received an intraperitoneal injection of 2mg cyclophosphamide (CY). The other group (left panel) received PBS injections. Four days later, mice were vaccinated with 1×106 TC-1 cells, mock-infected or infected ex vivo with Ad.Co or Ad.IR-E1A/TRAIL at an MOI of 500 pfu/cell. Growth of primary tumors was recorded over a period of 35 days. N=5B) Analysis of frequencies of IFNγ-producing E7 specific T-cells. Shown are the frequencies of IFNγ producing T-cells specific to the HPV16 E749-57 carrying the H-2Db restricted peptide (RAHYNIVTF) or an unrelated control peptide. N=3 animals per group.