TABLE 3.
Results of challenge study 1 for titers of neutralizing antibodies in sera of monkeys challenged with 104 PFU of wt DEN1WP
| Monkey | PRNT50−1 of DEN1 antibodies on challenge dayb:
|
||||
|---|---|---|---|---|---|
| Pre | 0 | 7 | 14 | 30 | |
| CE6G | NA | <10 | <10 | 160 | 640 |
| CE68 | NA | <10 | <10 | 160 | 640 |
| 810 | NA | <10 | <10 | 40 | 320 |
| KPJc | 160 | 80 | 640 | 10,240 | 10,240 |
| KJPc | 80 | 40 | 1,280 | 10,240 | 5,120 |
| KGVc | 80 | 640 | 1,280 | 1,280 | 640 |
a
Pre, antibody titer at conclusion of initial study of infectivity of DEN1mutF, 12 months prior to challenge. NA, not applicable.
b
Monkeys received ∼104 PFU of wt DEN1WP subcutaneously.
c
Received ∼104 PFU of DEN1mutF 12 months prior to challenge.