TABLE 4.

Correlations of pre- and post-DIO parameters in rats (n = 12) subjected to a HED for 16 wk

	Pre-DIO		Post-DIO
	Leptin sensitivity	MTII sensitivity	Plasma leptin	AUC insulin	Visceral obesity	Liver weight	PVN MC receptor binding	VMH MC receptor binding	PVN CRHimmuno-reactivity
Pre-DIO
Leptin sensitivity	1.000
MTII sensitivity	0.042, P = 0.897	1.000
Post-DIO
Plasma leptin	0.741, P = 0.006	−0.056, P = 0.863	1.000
AUC insulin	0.287, P = 0.366	0.147, P = 0.649	0.399, P = 0.199	1.000
Visceral obesity	0.608, P = 0.036	0.007, P = 0.983	0.867, P < 0.0001	0.629, P = 0.028	1.000
Liver weight	0.720, P = 0.008	0.294, P = 0.354	0.608, P = 0.036	0.434, P = 0.159	0.587, P = 0.045	1.000
PVN MC receptor binding	0.385, P = 0.217	−0.664, P = 0.018	0.434, P = 0.159	−0.049, P = 0.880	0.399, P = 0.199	0.077, P = 0.812	1.000
VMH MC receptor binding	0.084, P = 0.795	−0.056, P = 0.863	0.322, P = 0.308	0.070, P = 0.829	0.210, P = 0.513	0.483, P = 0.112	0.350, P = 0.265	1.000
PVN CRH immunoreactivity	0.175, P = 0.587	0.755, P = 0.005	0.147, P = 0.649	−0.021, P = 0.948	0.280, P = 0.379	−0.084, P = 0.795	0.685, P = 0.014	−0.154, P = 0.633	1.000

Correlation coefficient (Spearman’s ρ) and corresponding P values are given for each pairing. Significant correlations are given in bold.