TABLE 1.

Susceptibility of B6 mice, wild type or defective in granule exocytosis- or Fas-mediated cytotoxicity, to i.v. infection with MVE

Dose (PFU)	Mouse strain	No./group	% Mortalitya	AST ± SEMa
0.1	Wild type	27	59	10.3 ± 0.6
	perf−/−	12	33	11.0 ± 0.7
	gzmA×B−/−	18	281	11.6 ± 0.6
	perf × gzmA×B−/−	6	33	11.0 ± 1.0
	gld	10	40	12.3 ± 1.5
	lpr	6	33	14.0 ± 01
102	Wild type	70	46	11.6 ± 0.4
	perf−/−	15	201	12.3 ± 2.2
	gzmA×B−/−	20	25	10.8 ± 1.5
	perf × gzmA×B−/−	19	32	12.5 ± 0.3
	gld	11	27	11.7 ± 0.7
	lpr	11	55	11.3 ± 1.1
103	Wild type	9	56	12.0 ± 0.8
	perf−/−	16	38	12.8 ± 0.7
105	Wild type	20	40	10.9 ± 0.8
	perf−/−	12	33	13.3 ± 1.01
	gld	14	36	12.8 ± 1.0
	lpr	10	801	10.8 ± 0.6
108	Wild type	19	100	5.5 ± 0.2
	perf−/−	10	100	6.6 ± 0.23
	gzmA×B−/−	6	100	6.2 ± 0.4
	perf × gzmA×B−/−	5	100	9.4 ± 1.43
	gld	10	100	6.6 ± 0.32
	lpr	5	100	5.8 ± 0.2

^aStatistical significance relative to groups of wild-type mice is indicated by superscript numbers as follows: 1, P ≤ 0.1; 2, P ≤ 0.05; and 3, P ≤ 0.01. Differences in mortality were assessed using Fisher's exact test, and differences in AST were assessed using the Mann-Whitney test.