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. 2006 Feb 1;34(2):721–733. doi: 10.1093/nar/gkj471

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© The Author 2006. Published by Oxford University Press. All rights reserved

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Methylation-induced rearrangement of human mitochondrial tRNA^Lys. (A) Cloverleaf secondary structure of the fully modified human mitochondrial tRNA^Lys. (B) The extended hairpin secondary structure of the unmodified transcript of human mitochondrial tRNA^Lys (left) is converted to the cloverleaf by methylation on N1-A9, as evidenced in a chimeric tRNA containing m¹A9 as single modified nucleotide (right). The methylation prevents an A9-U64 base pair (boxed) in the extended hairpin structure on the left. Modified nucleotides in bold are abbreviated according to references (96,122).