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. 2006 Feb 1;34(2):721–733. doi: 10.1093/nar/gkj471

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© The Author 2006. Published by Oxford University Press. All rights reserved

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Possible influence of a conserved methylation pattern in rRNA. An unmodified oligoribonucleotide derived from helix 45 of a bacterial small subunit rRNA shows two alternative conformations in equilibrium, with K around 3, favouring the structure shown on the upper right. Introduction of several methyl groups restricts conformation space and results in the equilibrium being shifted almost completely to the structure shown on the lower left. Modified nucleotides are abbreviated according to reference (24).