FIG. 2.

Conservation and diversity of the hmw1A-like and hmw2A-like core-binding domains sequences among invasive NTHi isolates. (a and c) Matrixes of pairwise similarities among the hmw1A-like core-binding domain sequences (a) and among the hmw2A-like core-binding domain sequences (c). Isolate code numbers are indicated in the column on the far left and on the row above. The hmwA sequences from prototype strain 12 were included in pairwise comparisons. Above the diagonals, values represent pairwise similarities among the aligned sequences of each group, where a value of 1.0000 indicates 100% identity. (b and d) Similarity plots of the hmw1A-like core-binding domain sequences (b) and the hmw2A-like core-binding domain sequences (d). Similarity score values are indicated on the left (vertical axis). Nucleotide positions, based on strain 12 sequences, are indicated below the graph (horizontal axis). The dotted lines represent average similarities across the entire alignments.