TABLE 5.
Motif patterns in the HMW1-like and HMW2-like core-binding domain sequencesa
| Strain no. (group) | Positions and <motif> | Combined P value | E valueb | |||||
|---|---|---|---|---|---|---|---|---|
| 188 (HMW1) | (1 <3> 8) | (18 <6> 25) | (32 <5> 39) | (46 <1> 57) | (75 <4> 88) | (107 <2> 115) | 7.4E-51 | 1.5E-49 |
| 56 (HMW1) | (1 <3> 8) | (18 <6> 25) | (32 <5> 39) | (46 <1> 57) | (75 <4> 88) | (107 <2> 115) | 7.4E-51 | 1.5E-49 |
| 12 (HMW1) | (1 <3> 8) | (18 <6> 25) | (32 <5> 39) | (46 <1> 57) | (75 <4> 88) | (107 <2> 115) | 7.4E-51 | 1.5E-49 |
| 142 (HMW1) | (1 <3> 8) | (18 <6> 25) | (32 <5> 39) | (46 <1> 57) | (75 <4> 88) | (107 <2> 115) | 7.4E-51 | 1.5E-49 |
| 157 (HMW1) | (1 <3> 8) | (18 <6> 25) | (32 <5> 39) | (46 <1> 57) | (75 <4> 88) | (107 <2> 115) | 7.4E-51 | 1.5E-49 |
| 91 (HMW2) | (1 <3> 8) | (16 <6> 23) | (38 <5> 45) | (53 <1> 64) | (79 <4> 92) | (110 <2> 118) | 1.6E-47 | 3.2E-46 |
| 143 (HMW2) | (1 <3> 8) | (17 <6> 24) | (39 <5> 46) | (53 <1> 64) | (82 <4> 95) | (113 <2> 121) | 2.5E-44 | 5.0E-43 |
| 56 (HMW2) | (1 <3> 8) | (16 <6> 23) | (37 <5> 44) | (52 <1> 63) | (78 <4> 91) | (109 <2> 117) | 3.0E-44 | 6.1E-43 |
| 12 (HMW2) | (1 <3> 8) | (16 <6> 23) | (37 <5> 44) | (52 <1> 63) | (78 <4> 91) | (109 <2> 117) | 3.0E-44 | 6.1E-43 |
| 188 (HMW2) | (1 <3> 8) | (16 <6> 23) | (37 <5> 44) | (52 <1> 63) | (72 <4> 85) | (109 <2> 117) | 3.0E-44 | 6.1E-43 |
| 157 (HMW2) | (1 <3> 8) | (17 <6> 24) | (39 <5> 46) | (54 <1> 65) | (80 <4> 93) | (111 <2> 119) | 4.8E-43 | 9.7E-42 |
| 161 (HMW2) | (1 <3> 8) | (16 <6> 23) | (37 <5> 44) | (52 <1> 63) | (78 <4> 91) | (109 <2> 117) | 5.0E-42 | 1.0E-40 |
| 72 (HMW2) | (1 <3> 8) | (17 <6> 24) | (39 <5> 46) | (54 <1> 65) | (80 <4> 93) | (111 <2> 119) | 6.7E-42 | 1.3E-40 |
| 72 (HMW1) | (1 <3> 8) | (18 <6> 25) | (32 <5> 39) | (46 <1> 57) | (77 <4> 90) | (108 <2> 116) | 2.6E-41 | 5.2E-40 |
| 142 (HMW2) | (1 <3> 8) | (18 <6> 25) | (35 <5> 42) | (49 <1> 60) | (80 <4> 93) | (111 <2> 119) | 3.0E-41 | 6.0E-40 |
| 152 (HMW2) | (1 <3> 8) | (17 <6> 24) | (39 <5> 46) | (54 <1> 65) | (80 <4> 93) | (111 <2> 119) | 5.4E-41 | 1.1E-39 |
| 161 (HMW1) | — | (11 <6> 18) | (32 <5> 39) | (46 <1> 57) | (80 <4> 93) | (111 <2> 119) | 2.8E-40 | 5.6E-39 |
| 143 (HMW1) | — | (11 <6> 18) | (32 <5> 39) | (47 <1> 58) | (73 <4> 86) | (104 <2> 112) | 1.5E-38 | 2.9E-37 |
| 152 (HMW1) | (1 <3> 8) | (18 <6> 25) | (32 <5> 39) | (46 <1> 57) | (77 <4> 90) | (109 <2> 117) | 3.0E-37 | 6.1E-36 |
| 91 (HMW1) | — | (11 <6> 18) | (33 <5> 40) | (47 <1> 58) | (81 <4> 94) | — | 6.6E-33 | 1.3E-31 |
The motifs (multilevel consensus sequences) represented in the sequences were as follows: 1, FRFNNVSLNGTG; 2, (Y/H)WN(V/L)(T/S)SLN(V/L); 3, D(V/I)HKNI(T/S)L; 4, K(F/L)(D/E)G(T/E)(L/I)NISG(N/K)(V/I)(T/N); 5, IT(A/G)QGTIT; and 6, (A/T)(K/A/G)Q(S/D)(V/I)AFE. The number order of the motifs is that automatically generated by the MEME program and does not correspond to the position in the sequences. Motif alignment displays occurrences of the motifs (multilevel consensus sequences) within each sequence in both HMW1 and HMW2-like groups. Numbers on the left and on the right identify the amino acid positions where the motif begins and ends.
The E value is the combined P value multiplied by the number of sequences in the HMW-like dataset.