FIG. 4.

TNFR1 deficiency but not TNFR2 deficiency reduces fibrin deposition during acute T. gondii infection (Toxo). WT, TNFR1-deficient, and TNFR2-deficient mice were sham infected (open bars) or infected perorally with 10 ME49 T. gondii cysts (closed bars). Levels of hepatic fibrin were measured on day 8 after the initiation of infection. Data depict the median and interquartile range (n = 10 to 15 mice per group). The dashed line depicts the limit of detection. In comparison with T. gondii-infected WT mice, T. gondii-infected TNFR1-deficient mice produce significantly less fibrin (P < 0.0001) but TNFR2-deficient mice do not. KO, knockout.