TABLE 1.
Vaccine antigen-specific Th1/Th2 ratios in PBMC-DC cocultures from 12-month-old children and adults
| Ratio | Median (interquartile range)a
|
|||
|---|---|---|---|---|
| 12-mo-old children
|
Adults
|
|||
| Diphtheria toxoid | Tetanus toxoid | Diphtheria toxoid | Tetanus toxoid | |
| IFN-γ/IL-5 | 0.2 (0.1-1.0) | 0.4 (0.1-1.6) | 55.2b (3.6-196.5) | 25.8b (2.3-40.3) |
| IFN-γ/IL-13 | 0.4 (0.1-1.7) | 0.1 (0.0-1.2) | 19.9c (1.5-32.5) | 6.8b (1.7-18.1) |
a
The IFN-γ/IL-5 and IFN-γ/IL-13 ratios were calculated for each individual. The statistical significance of differences between 12-month-old children and adults was assessed using the Mann-Whitney U test.
b
P = 0.001 compared to value for 12-month-old children.
c
P = 0.004 compared to value for 12-month-old children.