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. 2006 Feb;74(2):1284–1296. doi: 10.1128/IAI.74.2.1284-1296.2006

FIG. 10.

FIG. 10.

Histopathology induced by intranasal SEB challenge in STAT4-deficient mice. Age-matched STAT4-deficient or -sufficient HLA-DQ8 transgenic mice were challenged intranasally with either PBS or 20 ng of SEB on days 0, 3, and 6. Mice were sacrificed on day 8. After harvest of BAL fluids on day 8, lungs were collected in buffered formaldehyde and embedded in paraffin. Thin sections were stained in hematoxylin and eosin (A, B, and C); deparaffinized sections were stained with anti-MBP antibody (D, E, and F). (A and D) PBS-treated, STAT4-deficient DQ8 transgenic mice; (B and E) STAT4-deficient DQ8 transgenic mice treated with 20 ng SEB; (C and F) STAT4-sufficient DQ8 transgenic mice treated with 20 ng of SEB. Magnification, ×160.