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. 2006 Feb;74(2):1284–1296. doi: 10.1128/IAI.74.2.1284-1296.2006

FIG. 11.

FIG. 11.

Histopathology induced by intranasal SEB challenge in STAT4-deficient mice. Age-matched STAT4-deficient or STAT4-sufficient HLA-DQ8 transgenic mice were challenged with either PBS or 1 μg of SEB on days 0, 3, and 6. Mice were sacrificed on day 8, and lungs were collected in buffered formaldehyde and embedded in paraffin. Thin sections were stained in hematoxylin and eosin. (A to C) PBS-treated, STAT4-deficient DQ8 transgenic mice; (D to F) STAT4-deficient DQ8 transgenic mice treated with SEB; (G to I) STAT4-sufficient DQ8 transgenic mice treated with SEB. (A, D, and G) Lower magnification; (B, E, and H) higher magnification. (C, F, and I) Sections in the boxed areas are magnified for clarity. *, goblet cell hyperplasia; arrows, eosinophils.