AE	Adverse event
BBB	Blood Brain Barrier
CGI-C	Clinician Global Impression of Change
CGI-S	Clinical Global Impression Severity
CI	Confidence Interval
COMT	Catechol O-methyltransferase
DDCi	Dopa decarboxylase inhibitor
IQR	Interquartile range
LCE	Levodopa/carbidopa/entacapone
LEDD	Levodopa equivalent daily dose
MAOI	Monoamine oxidase inhibitors
MDS-UPDRS	Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale
NMSS	Non-Motor Symptoms Scale
PGI-C	Patient Global Impression of Change
PD	Parkinson’s disease
PDQ-8	Parkinson’s Disease Questionnaire-8
QoL	Quality of life
SAE	Serious adverse event
SD	Standard deviation
WOQ-19	Wearing-off Questionnaire-19