TABLE 1.
Survival and viremia following infection of swine with virulence-rescued E70ΔNL recombinant virusesa
| Virus | No. of survivors/total | Mean time to death (days) ± SEM | Viremia
|
||
|---|---|---|---|---|---|
| Mean time to onset (days) ± SEM | Mean titer (log10 TCID50/ml) ± SEM | Max titer (log10 TCID50/ml) ± SEM | |||
| E70ΔNL | 4/4 | 9 ± 3.0 | 3.4 ± 1.0 | 3.8 ± 0.8 | |
| E70C4 | 0/2 | 5 ± 1.5 | 3 ± 1.0 | 7.8 ± 0.2 | 8.0 ± 0.2 |
| E70 M1 | 0/6 | 6.3 ± 0.2 | 3 ± 0.0 | 7.6 ± 0.2 | 8.1 ± 0.2 |
a
Rescued E70ΔNL recombinants selected in the in vivo marker rescue experiments are designated E70C4 for the cosmid C4- derived isolate and E70 M1 for the virus isolate selected using the plasmid subclone pM1.