FIG. 7.

Model depicting the interactions of recombinant HIV-1 IN subunits in solution. White circles, IN monomers that interact to form dimers. This population of IN subunits possibly forms the majority of IN in recombinant HIV-1 IN preparations. The majority of these subunits can perform half-site integration but not full-site integration due to their inability to assemble two viral DNA ends correctly. Gray circles, IN monomers possessing the ability to form dimers and multimers which can correctly assemble on two viral DNA ends allowing full-site integration.