Fig. 2.

The frequency of radiation-induced gene mutations at the tk and hprt in TK6 (Left) and WTK1 (Right) cells. Both control and mICAD-transduced cells were used in all experiments. In each experiment, mean and standard deviation were calculated from three independent experiments. Radiation-induced gene mutation frequencies at the tk and hprt gene locus of control and in mICAD-transduced cells were shown. In both TK6 and WTK1 cells, the results were statistically significant (P < 0.05). Background mutation frequencies (from nonirradiated cell populations) were subtracted in each of the experiments shown.