Table 1. Inhibition of HPV16 PsV transduction of HeLa cells.
| α-defensins | Supplier* | IC50† | 95% CI | Toxicity |
|---|---|---|---|---|
| HNP-1 | — | 5 | 3.2-6.6 | >100 |
| HNP-1 | American Peptide | 6 | 5.2-7.7 | >32 |
| HNP-1 | Bachem | 6 | 3.6-8.5 | >100 |
| HNP-1 | Pepnet | 5 | 3.8-7.3 | >100 |
| HNP-1 (HaCaT cells) | Pepnet | 9 | 3.7-18.6 | >100 |
| HNP-1 (293TT cells) | Pepnet | 8 | 6.0-10.1 | >100 |
| HNP-1 (serum-free medium) | — | 3 | 1.1-6.1 | 50 |
| HNP-2 | American Peptide | 4 | 2.5-7.6 | >100 |
| HNP-3 | Pepnet | 10 | 6.9-13.1 | >100 |
| HNP-4 | — | 21 | 6.9-60.6 | 50 |
| HD-5 | — | 0.6 | 0.55-0.75 | >100 |
| HD-5 | Pepnet | 0.6 | 0.59-0.63 | >100 |
| HD-5 (serum-free medium) | — | 0.5 | 0.30-0.72 | 50 |
| HD-6 | — | — | — | 50 |
| β-defensins | ||||
| HBD-1 | Pepnet | — | — | >390 |
| HBD-2 | Pepnet | 190 | 178-203 | >430 |
| Other human antimicrobials | ||||
| Heparin (H4784) | Sigma Aldrich | 2 | 1.7-1.9 | >160 |
| Histatin-5 | Bachem | — | — | >30 |
| Lactoferrin (L4894) | Sigma Aldrich | 62 | 50.7-76.8 | 780 |
| Lactoferrin N-lobe | Bachem | — | — | >100 |
| Liver-expressed antimicrobial peptide-1 | American Peptide | — | — | >100 |
| Liver-expressed antimicrobial peptide-2 | American Peptide | — | — | >100 |
| LL-37 | Phoenix Peptides | 9 | 6.3-13.7 | 15 |
| Lysozyme (neutrophil) | Sigma Aldrich | — | — | >100 |
| Secretory leukocyte protease inhibitor | R&D Systems | — | — | >100 |
All values are given in μg/ml; CI, confidence interval.
*
Dashes imply that compound was synthesized in-house.
†
Dashes imply that no inhibitory effect was observed at highest noncytotoxic dose.