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. 2006 Jan 19;103(5):1593–1598. doi: 10.1073/pnas.0508901103

Fig. 5.

Fig. 5.

Antidepressant-like effect in the FST induced by intrahippocampal injection of leptin. Artificial cerebrospinal fluid (vehicle) or rat leptin at different doses (0.25, 1.0, and 3.0 μg per side) was infused into the hippocampus. Three days later, the FST behavior recorded in the first 5 min of the training session and the 5-min test session was scored. Vehicle, n = 18; leptin 0.25 μg, n = 6; leptin 1.0 μg, n = 13; leptin 3.0 μg, n = 6. (A) Training session (first 5 min). Immobility, F(3,39) = 1.165, P = 0.3354; swimming, F(3,39) = 1.276, P = 0.2961; climbing, F(3,39) = 0.1427, P = 0.934. (B) Test session. Immobility, F(3,39) = 4.509, P < 0.01; swimming, F(3,39) = 3.472, P < 0.05; climbing, F(3,39) = 1.769, P = 0.1689. Post hoc tests, *, P < 0.05; **, P < 0.01 compared with vehicle controls.