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MS-275 elicits an increase in Ac-H3 content in the frontal cortex and hippocampus but not in the striatum. Each value is the mean ±SE of three mice; *, P < 0.05 (one-way ANOVA followed by Bonferroni multiple comparison). The Ac-H3/H1 ratio is expressed in arbitrary immunoreactivity units (A.U.). Values are normalized to vehicle (VEH)-treated mice (see Materials and Methods). Mice were treated with MS-275 2 h before measurements.
