Fig. 3.

Covalently modified histones in the frontal cortex of MS-275- and 3′-NH₂-MS-treated mice. Gray bars, MS-275, 120 μmol/kg; black bars, 3′-NH₂-MS, 120 μmol/kg. Mice were injected s.c. 2 h before measurements. ^*, P < 0.05; ^**, P < 0.01 when compared with VEH (control)-treated mice. Data are expressed as the mean ± SE of five animals. P-Ac-H3, phosphorylated Ac-H3; Ac-H4, acetylated histone 4; Dimethyl-H3, dimethylhistone 3. For details on the antibodies see Materials and Methods.