Fig. 1.

Ts65Dn cerebellum is the same size as euploid at birth, but shows specific growth deficits by P6. (a) Midline sagittal sections demonstrate grossly normal morphology but diminished growth in Ts65Dn cerebellum compared to euploid. The EGL is visible in posterior folia of both genotypes at P14 but has disappeared by P24. (b) Graphic representation of the midline cerebellar area as a fraction of total brain. An asterisk indicates a significant difference (P ≤ 0.05, Student's t test). The number of animals of each genotype is indicated.